Resting-State fMRI Biomarkers of Cognitive Dysfunction in Sub-health Patients with Spleen Qi Deficiency Syndrome and Kidney Qi Deficiency Syndrome Based on Independent Component Analysis
- VernacularTitle:基于独立成分分析脾气虚证与肾气虚证亚健康患者认知功能损伤的静息态fMRI脑影像学表征
- Author:
Sitong FENG
1
;
Ziyao WU
;
Linrui DONG
;
Yanzhe NING
;
Hongxiao JIA
Author Information
- Publication Type:Journal Article
- Keywords: Spleen qi deficiency syndrome; Kidney qi deficiency syndrome; Sub-health; Resting state; Independent component analysis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(11):3133-3140
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the neuroimaging mechanisms of cognitive impairment in sub-health patients with spleen qi deficiency syndrome and kidney qi deficiency syndrome using independent component analysis.Methods 40 sub-health patients with spleen qi deficiency syndrome and 40 kidney qi deficiency syndrome were recruited.All subjects underwent repeated neuropsychological testing and resting-state functional magnetic resonance imaging(fMRI)scans.Independent component analysis was used to compare functional connectivity differences between the two groups of subjects in the default mode network(DMN),frontoparietal network(FPN),dorsal attention network(DAN),and executive control network(ECN).The relationship between the differences in functional connectivity and cognitive function in the two groups of patients was also analyzed.Results In sub-health patients with spleen deficiency syndrome,the DMN included six brain regions,including the bilateral superior parietal lobule,left inferior occipital gyrus,and left lingual gyrus.The FPN included four brain regions,including the left superior parietal gyrus and the left caudate nucleus,the DAN included two brain regions,including the right superior temporal gyrus and the left medial frontal gyrus,and the ECN included the left central parietal lobule.The functional connectivity between the spleen qi deficiency syndrome symptom score and the left middle temporal gyrus and right superior temporal gyrus showed a significant positive correlation(r=0.371,P=0.028).In sub-health kidney qi deficiency syndrome patients,the DMN included six brain regions,including the left superior temporal gyrus,left precuneus,and right angular gyrus,the FPN included three brain regions,including the right middle temporal gyrus and right superior temporal gyrus,the DAN included four brain regions,including the right wedge lobe and the left medial frontal superior gyrus,and the ECN included the left central paracentral lobule and the right central posterior gyrus.Among these,the functional connectivity between the left wedge lobe and the left frontal middle gyrus showed a significant positive correlation with the syndrome score of kidney qi deficiency(r=0.404,P=0.016).Conclusion Sub-health patients with spleen qi deficiency syndrome and kidney qi deficiency syndrome exhibit different neuroimaging bases for cognitive impairment,providing neuroimaging evidence to elucidate the differences in the cognitive psychological connotation of the theories of"spleen in storing idea"and"kidney storing will".
