Abnormalities in Large-Scale Brain Network Resting-State Functional Connectivity in Sub-Health Patients with Spleen Qi Deficiency Syndrome
- VernacularTitle:亚健康脾气虚证患者大尺度脑网络内及网络间静息态功能连接异常研究
- Author:
Sitong FENG
1
;
Ziyao WU
1
;
Yanzhe NING
1
;
Hongxiao JIA
1
Author Information
- Publication Type:Journal Article
- Keywords: Spleen qi deficiency syndrome; Sub-health; Resting-state; Large-scale brain networks; Functional connectivity
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(11):3126-3132
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the neuroimaging mechanisms of sub-health patients with spleen qi deficiency syndrome based on large-scale brain network resting-state functional connectivity.Methods Thirty-seven sub-health patients with spleen qi deficiency syndrome and 37 healthy controls were enrolled.All subjects underwent resting-state functional magnetic resonance imaging(fMRI)scans.Functional connectivity within and between large-scale brain networks was analyzed and compared between the two groups.The correlation between abnormal changes in brain network functional connectivity in the sub-health spleen qi deficiency syndrome group and spleen qi deficiency syndrome scores was also analyzed.Results Compared with the healthy control group,the sub-health spleen deficiency syndrome group showed significantly reduced functional connectivity within and between brain networks,including the visual network,sensorimotor network,dorsal attention network,frontoparietal network,and default mode network(P<0.05,NBS correction,5000 permutations).Among these,the functional connectivity between the sensorimotor network and the frontoparietal network(r=-0.357,P=0.030)and between the dorsal attention network and the frontoparietal network(r=-0.360,P=0.029)showed a significant negative correlation with the spleen qi deficiency syndrome score.Conclusion Abnormal changes in functional connectivity within and between large-scale brain networks in sub-health patients with spleen deficiency syndrome provide further neuroimaging evidence for the cognitive psychological connotation of the"spleen in storing idea"theory.
