Relationship Between Cognitive Function and Cardio-Electroencephalographic Coupling in Coronary Heart Disease Patients with Heart-Qi Deficiency Pattern
- VernacularTitle:心气虚证冠心病患者的认知功能和心脑电耦合的关系研究
- Author:
Bixiu HUO
1
;
Bin WANG
;
Yunhe ZHANG
;
Sitong FENG
;
Yanzhe NING
;
Hongxiao JIA
Author Information
- Publication Type:Journal Article
- Keywords: Coronary heart disease; Cognitive function; Maximal information coefficient; Heart-brain coupling
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(11):3108-3118
- CountryChina
- Language:Chinese
- Abstract: Objective To explore their inter-relationship,cognitive performance and cardio-electroencephalographic coupling in coronary heart disease(CHD)patients with heart-qi deficiency pattern were characterized.Methods Thirty CHD patients who met the diagnostic criteria for heart-qi deficiency were enrolled.Thirty healthy volunteers without heart-qi deficiency or CHD served as controls.Cognitive function was assessed with the repeatable battery for the assessment of neuropsychological status(RBANS).Simultaneous resting-state electrocardiogram and electroencephalogram were recorded,and the strength of heart-brain coupling was quantified by calculating the maximal information coefficient(MIC)between heart-rate variability(HRV)and EEG signals.Results Compared with controls,heart-qi deficiency CHD patients showed lower RBANS total scores and reduced performance in immediate memory,visuospatial/constructional ability,and attention.Significant between-group differences in HRV-EEG MIC values were observed at several channels(P<0.05).In patients,the MIC values for HRV-Beta(channel FC1)and HRV-Delta(channel F2)were positively correlated with RBANS total score(P<0.05).Conclusion CHD patients with heart-qi deficiency exhibit impaired cognition and altered cardio-electroencephalographic coupling.These findings suggest that heart-brain interactions may contribute to the pathophysiological mechanisms underlying cognitive decline in this population.
