Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic Review
10.1097/FM9.0000000000000276
- VernacularTitle:Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic Review
- Author:
Jinrui XIONG
1
;
Ling-Jun LI
;
Yongping ZHANG
;
Zhihong ZHANG
;
Yue YANG
;
Huan HU
;
Jinhong LIU
;
Zimeng CHEN
;
Peng HUANG
;
Mengjiao LIU
Author Information
1. School of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China
- Publication Type:Journal Article
- Keywords:
Hyptertensive disorders of pregnancy;
Metabolomics;
Preeclampsia;
Gestational hypertension;
Intergenerational associations
- From:
Maternal-Fetal Medicine
2025;07(3):157-165
- CountryChina
- Language:English
-
Abstract:
Objective::To examine the impact of hypertensive disorders of pregnancy (HDP) on offspring metabolomics.Methods::We searched five databases: PubMed, Ovid Embase, MEDLINE, Web of Science, and China National Knowledge Infrastructure, and included studies that reported metabolomics among human offspring born to HDP-complicated pregnancies.Results::Database search yielded 4054 articles, and after full-text screening, ten observational studies met inclusion criteria. Half of the studies had a sample size of less than 100 and were all observational studies in preeclampsia (PE) and gestational hypertension.Neonates were the most focused group in all included studies. Offspring born to HDP-complicated pregnancies exhibited statistically significant variations in blood metabolomics compared to their counterparts, characterized by amino acids, lipids, carnitine, and others (e.g., 1α,25-(OH) 2-D). Most studies reported a significant increase in differential metabolites of offspring born to HDP-complicated pregnancies. Four studies ( n = 1109) measured lipids-related metabolites, and all consistently showed that offspring born to PE-complicated pregnancies had significantly higher concentrations than non-PE exposed offspring. Conclusion::The existing evidence suggests an intergenerational effect of HDP on offspring metabolomics. Long-term follow-up studies are needed to advance the health effects of related adverse health outcomes and inform the prevention of offspring’s health.
