Research Progress on Signaling Pathways Related to Chondrocyte Apoptosis in the Treatment of Osteoarthritis with Traditional Chinese Medicine Monomers
10.11842/wst.20250113008
- VernacularTitle:中药单体治疗骨关节炎中软骨细胞凋亡相关信号通路的研究进展
- Author:
Weiren WANG
1
;
Siwen KANG
;
Wei WEI
;
Guangzhi ZHOU
;
Dongxu TAI
Author Information
1. 辽宁中医药大学 沈阳 110847
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
Chondrocyte apoptosis;
Traditional Chinese medicine monomers;
Signal pathway
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(11):3183-3195
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis is a chronic degenerative joint disorder that adversely affects the quality of life of patients.Its pathological characteristics mainly involve the degeneration,destruction,and functional loss of articular cartilage.As one of the most crucial structures in the joint,articular cartilage is an avascular tissue composed of extracellular matrix synthesized by sparsely distributed chondrocytes.Chondrocyte apoptosis is one of the programmed cell death modalities of chondrocytes.During the normal physiological process,the proliferation and apoptosis of chondrocytes maintain a dynamic equilibrium,jointly safeguarding the homeostasis of articular cartilage.However,in the osteoarthritis process,the stimulation of related cytokines after tissue damage induces an imbalance between chondrocyte proliferation and apoptosis,resulting in excessive chondrocyte apoptosis,and subsequently leading to the degradation and degeneration of cartilage.Clinically,traditional Chinese medicine and its related therapeutic approaches remain one of the principal means for treating osteoarthritis in China.The traditional Chinese medicine,which are bioactive compounds extracted from traditional herbal medicines,has gradually gained recognition thanks to their convenient to take and remarkable therapeutic effect.Therefore,this review takes the signaling pathways involved in the inhibition of chondrocyte apoptosis by traditional Chinese medicine as the entry point,systematically retrieves and screens and summarizes relevant studies at home and abroad in the past five years,and analyzes the mechanism of action of related signaling pathways in the treatment of chondrocyte apoptosis in osteoarthritis by traditional Chinese Medicine,providing new options for the pharmacological treatment of osteoarthritis.
