The correlation between erythrocyte sedimentation rate and cellular immunity in children with Mycoplasma pneumoniae pneumonia of different ages
10.13431/j.cnki.immunol.j.20240093
- VernacularTitle:不同年龄支原体肺炎患儿红细胞沉降率水平与细胞免疫的相关性
- Author:
Qiuxia LI
1
;
Dandan SHI
1
;
Longbing HE
1
;
Qin SHEN
1
Author Information
1. 223800,江苏省人民医院宿迁医院
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumoniae;
Sedimentation rate;
Cellular immunity;
Recurrent respiratory tract infections
- From:
Immunological Journal
2024;40(8):670-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between erythrocyte sedimentation rate(ESR)and cellular immunity in children with Mycoplasma pneumoniae pneumonia(MPP)of different ages.Methods 195 children diagnosed with Mycoplasma pneumoniae pneumonia admitted to our hospital from January 2020 to December 2023 were selected as the study subjects.All patients were divided into three groups based on age:74 infants and young children(≤3 years old),63 young children(3-6 years old),and 58 older children(≥6 years old).Compare clinical data,imaging information,and cellular immune levels of children of different age groups,and analyze the correlation between ESR levels and cellular immune levels through EmpowerStats stratified interaction test.MMP patients were divided into RRTI group(n=63)and non RRTI group(n=132)based on whether they had recurrent respiratory tract infection(RRTI).Clinical data of the two groups were compared,and the Cox proportional hazards model was used to analyze the correlation between ESR levels and the occurrence of RRTI in MPP patients at different age groups.ESR levels were divided into a quintile array from low to high,and a subgroup analysis was conducted on the correlation between ESR levels and the occurrence of RRTI in MPP patients.The restricted cubic spline model was used to analyze the dose-response relationship between ESR levels and the occurrence of RRTI in MPP patients.Results Children of different ages had fever peaks,fever duration,persistent high fever>7 days,difficulty breathing,asthma,wet rales,wheezing,extrapulmonary complications,neutrophil count(ESR),Eosinophil count,C-reactive protein(CRP),lactate dehydrogenase(LDH),D-dimer,and whether RRTI were present were statistically significant(P<0.05).Compared with MPP patients in the infant and toddler group,the incidence of lobular parenchymal infiltration,interstitial infiltration,and CD8+levels in the younger and older infant groups were significantly reduced(P<0.05),while the incidence of pulmonary parenchymal infiltration,pleural effusion,CD3+,CD4+levels,and CD4+/CD8+ratio levels were significantly increased(P<0.05).EmpowerStats stratified interaction test analysis showed that after adjusting for other factors such as heat peak,heat duration,and dyspnea,the relationship between ESR levels and cellular immune indicators still exists in MPP patients of different ages.There were significant differences in age,age group,heat peak,ESR,CRP,Fibrinogen(Fib),D-dimer,lobular parenchymal infiltration,segmental parenchymal infiltration,atelectasis,pleural effusion,CD3+,CD4+,CD8+,and CD4+/CD8+ratio between the RRTI and non RRTI groups(P<0.05).The Cox proportional risk model results showed that after adjusting for variables such as CRP and pleural effusion,ESR levels remained a protective factor for RTTI in MPP patients,and there was interaction between subgroups.The results of the restricted cubic spline model show that there is no non-linear dose-response relationship between ESR levels and RRTI occurrence in MPP patients of different ages.Conclusion There is a correlation between ESR levels and cellular immunity in children with MPP of different ages,and the relationship is stable.ESR level is a protective factor for MPP patients with RRTI.
