Research progress on the effects of monoamine neurotransmitters on clinical manifestations of polycystic ovary syndrome
10.3760/cma.j.cn101441-20250130-00043
- VernacularTitle:单胺类神经递质对多囊卵巢综合征临床表现相关影响的研究进展
- Author:
Yunting HUANG
1
;
Yanru LOU
1
;
Xiaohui LI
1
;
Yuchuan HUANG
1
;
Jialin LI
1
;
Tian TIAN
1
;
Jie YAN
1
;
Rui YANG
1
Author Information
1. 北京大学第三医院妇产科生殖医学中心 国家妇产疾病临床医学研究中心 辅助生殖教育部重点实验室 北京市生殖内分泌与辅助生殖技术重点实验室，北京 100191
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Dopamine;
Norepinephrine;
5-hydroxytryptamine;
Pathogenesis;
Clinical manifestations
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):729-734
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder, with symptoms of menstrual disorders, hirsutisms, acne, and obesity. Studies have found that PCOS patients have a higher prevalence of anxiety, depression and sleep disorders than non-PCOS women, which may be related to the abnormal innervation. Meanwhile, it has been found that PCOS patients exhibit lower central level and higher peripheral levels of monoamine neurotransmitters (5-hydroxytryptamine, dopamine and norepinephrine). These imbalances can affect various clinical manifestations of PCOS, including the formation and development of metabolic and reproductive disorders, as well as anxiety and sleep disorders, through multiple pathways. This review summarizes recent research progress on the role of monoamine neurotransmitters in the physiological characteristics and clinical manifestations of PCOS patients, aiming to provide new insights into the neuroendocrine characteristics and pathogenesis of the syndrome.
