Pregnancy outcomes analysis in young patients with diminished ovarian reserve undergoing intrauterine insemination: a propensity score-matched cohort study
10.3760/cma.j.cn101441-20250520-00235
- VernacularTitle:年轻卵巢储备功能减退患者行宫腔内人工授精妊娠结局分析：一项倾向性评分匹配队列研究
- Author:
Qi JIA
1
;
Xiaofang DU
1
;
Bingnan REN
1
;
Jiaheng LI
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖健康医院，郑州 450052
- Publication Type:Journal Article
- Keywords:
Intrauterine insemination;
Diminished ovarian reserve;
Age;
Clinical pregnancy rate
- From:
Chinese Journal of Reproduction and Contraception
2025;45(11):1148-1151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pregnancy outcomes in patients ≤35 years old with diminished ovarian reserve (DOR) undergoing intrauterine insemination (IUI).Methods:A retrospective cohort study was conducted by analyzing the clinical data of 6 229 IUI cycles performed in patients aged ≤35 years at the Reproductive Health Hospital of the Third Affiliated Hospital of Zhengzhou University between June 2016 and March 2024. Based on serum anti-Müllerian hormone (AMH) levels, the subjects were divided into two groups: patients with AMH <1.1 μg/L were classified as the DOR group (489 cycles), and patients with AMH ≥1.1 μg/L were classified as the normal ovarian reserve (NOR) group (5 740 cycles). Propensity score matching (PSM) was applied to control for confounding factors, after 1∶1 PSM matching, 486 cycles were included in each group. Clinical pregnancy rate, miscarriage rate, live birth rate, biochemical pregnancy rate, and ectopic pregnancy rate were compared between the two groups by generalized estimating equations.Results:The clinical pregnancy rate was 21.19% (103/486) in DOR group and 24.07% (117/486) in NOR group, with no statistically significant difference ( P=0.294). The live birth rate was 18.31% (89/486) in DOR group and 20.16% (98/486) in NOR group, also without significant difference ( P=0.469). Additionally, no significant differences were observed in miscarriage rate, biochemical pregnancy rate, or ectopic pregnancy rate between the two groups (all P>0.05). Conclusion:In patients aged ≤35 years with DOR, pregnancy outcomes from IUI are comparable to those in young patients with NOR.
