Applications and prospects of needle-free injection technologies in vaccine delivery
10.16303/j.cnki.1005-4545.2025.11.28
- VernacularTitle:无针注射在疫苗递送中的应用与展望
- Author:
Qiang YANG
1
;
Yongfeng LI
;
Xin SONG
;
Huaji QIU
;
Yuan SUN
Author Information
1. 中国农业科学院哈尔滨兽医研究所动物疫病防控全国重点实验室,黑龙江哈尔滨 150069;黑龙江八一农垦
- Publication Type:Journal Article
- Keywords:
vaccine;
route of administration;
needle-free injection;
needle-based injection
- From:
Chinese Journal of Veterinary Science
2025;45(11):2525-2534
- CountryChina
- Language:Chinese
-
Abstract:
Needle-free injection(NFI)has emerged as a novel vaccine delivery technology,utilizing high-pressure jet streams to deliver vaccines into intradermal or subcutaneous tissues.In recent years,the application of this technology in the fields of medicine and veterinary medicine has a-chieved significant progress.Compared with traditional needle injection,the core advantages of NFI have been highlighted in several aspects:it has significantly improved vaccination efficiency,mak-ing it particularly suitable for mass vaccination campaigns;it has reduced animal stress;it has en-hanced the comfort of vaccination;it has more effectively induced immune responses;and it has a-voided the risk of needle contamination,thereby lowering the infection rate.However,NFI has also faced challenges such as high equipment costs,complex operation,and the need to improve market acceptance.Future research directions have focused on the development of new vaccines and adju-vants as well as the design and optimization of needle-free injectors to enhance their universality and safety among different populations.In summary,NFI has provided an important solution for the innovation of vaccine delivery systems by improving vaccination comfort and immune efficacy and has offered theoretical basis and technical references for its industrial development.
