A novel perspective on male testicular aging: Sertoli cell lysosomal dysfunction with intervention targets
10.3760/cma.j.cn101441-20250731-00321
- VernacularTitle:男性睾丸衰老新视角：睾丸支持细胞溶酶体功能障碍及其干预靶点
- Author:
Yunzhi LIN
1
;
Yulin XIONG
;
Zhiwen DENG
;
Zheng LI
;
Zhi ZHOU
Author Information
1. 上海科技大学生命与技术学院，上海 201210
- Publication Type:Journal Article
- Keywords:
Testis;
Aging mechanism;
Sertoli cells;
Lysosomal dysfunction
- From:
Chinese Journal of Reproduction and Contraception
2025;45(11):1124-1130
- CountryChina
- Language:Chinese
-
Abstract:
Male reproductive aging is characterized by degenerative changes in the structure and function of the testes. Testicular aging involves alterations in various types of cells, among which lysosomal dysfunction in Sertoli cells is particularly critical. Recent studies have shown that abnormal lysosomal acidification leads to impaired phagosome degradation, which fails to maintain normal nutrient cycling and thereby exacerbates damage to the testicular microenvironment. In addition, endoplasmic reticulum stress, mitochondrial dysfunction, and epigenetic changes are also important factors contributing to reproductive aging. Therefore, molecular intervention strategies targeting lysosomal dysfunction, mitochondrial oxidative stress, and endoplasmic reticulum stress, such as the use of lysosomal activators like ML-SA1 and antioxidants, may offer new therapeutic directions for alleviating male reproductive aging. Future research should further explore the interactions between these mechanisms and potential intervention targets to improve reproductive health and quality of life in middle-aged and older men.
