Research progress in the treatment of diminished ovarian reserve

VernacularTitle:卵巢储备功能减退的治疗研究进展
Author: Hejie WANG ¹ ; Jie LI ; Yuke FU ; Guiting YU ; Liping CHEN ; Jie CAI
Author Information

1. 宁波大学医学院，宁波　315211
Publication Type:Journal Article
Keywords: Diminished ovarian reserve; Regenerative medicine; Precision medicine
From: Chinese Journal of Reproduction and Contraception 2025;45(10):1067-1071
CountryChina
Language:Chinese
Abstract: Diminished ovarian reserve (DOR) is a major cause of female infertility, characterized by a complex and multifactorial etiology involving aging, genetic predisposition, environmental factors, and immune mechanisms. Therapeutic options for DOR remain limited, with no currently established treatments demonstrating consistently robust efficacy. Recent advances in regenerative medicine—including the use of mesenchymal stem cells and their derivatives, platelet-rich plasma and in vitro activation—have opened promising new avenues for ovarian function restoration. This review offers a comprehensive summary of research progress in DOR treatment over the past five years, covering hormonal therapies, assisted reproductive technologies, nutritional supplementation and lifestyle modifications, Traditional Chinese Medicine, targeted therapies, and regenerative medicine approaches, with the aim of providing guidance for clinical management of DOR.