Research progress on the effects of cigarette smoke on ovarian reserve and function
10.3760/cma.j.cn101441-20250124-00038
- VernacularTitle:香烟烟雾影响卵巢储备及功能的研究进展
- Author:
Shuyuan CHEN
1
;
Cuifang HAO
;
Duan LI
;
Xin DU
Author Information
1. 青岛大学中西医结合学科，青岛 266000
- Publication Type:Journal Article
- Keywords:
Ovarian reserve;
Cigarette smoke;
Apoptosis;
Oxidative stress;
DNA damage
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):746-750
- CountryChina
- Language:Chinese
-
Abstract:
Diminished ovarian reserve (DOR) is a decrease in the number of available follicles in the ovaries and the quality of oocytes, which in turn affects follicle development, ovulation and sex hormone secretion, resulting in decreased fertility. Harmful chemical components in cigarette smoke, such as nicotine and benzopyrene, can interfere with the hypothalamic-pituitary-ovarian axis and impair ovarian reserve and function through apoptosis, autophagy, oxidative stress and DNA damage, which can directly affect ovarian granulosa cells and oocytes, causing oocyte development disorders, increased apoptosis of granulosa cells, destroy reproductive endocrine homeostasis, lead to DOR and affect female fertility. At present, the molecular mechanism of premature ovarian dysfunction caused by cigarette smoke is not fully understood. In this paper, the molecular mechanism of cigarette smoke exposure affecting ovarian tissue and mediating ovarian function was reviewed, aiming to provide theoretical reference for the study of cigarette smoke induced DOR and affecting ovarian function, and to provide pregnant guidance for infertile women in bad environment and bad living habits.
