Classification and mechanism of active molecules against female reproductive aging
10.3760/cma.j.cn101441-20250119-00030
- VernacularTitle:抗女性生殖衰老活性分子的分类及作用机制
- Author:
Xiaoyue ZHANG
1
;
Wenpei XIANG
1
Author Information
1. 华中科技大学同济医学院生殖健康研究所，武汉 430030
- Publication Type:Journal Article
- Keywords:
Ovarian reserve;
Oxidative stress;
Female reproductive aging;
Active molecule
- From:
Chinese Journal of Reproduction and Contraception
2025;45(5):453-461
- CountryChina
- Language:Chinese
-
Abstract:
Female reproductive aging refers to the process that ovarian function gradually declines with age, leading to the decline of fertility and related physiological dysfunction. In recent years, the research on anti-female reproductive aging active molecules has become a hot spot in the medical field, aiming at delaying ovarian aging and improving reproductive health. In this paper, the main sources of anti-female reproductive aging molecules are reviewed, including natural products, endogenous molecules and synthetic small molecules, with emphasis on resveratrol, curcumin, soybean isoflavones, nicotinamide adenine dinucleotide precursors (such as nicotinamide mononucleotide) and mitochondrial targeting molecules. These molecules play an important role in delaying ovarian aging and maintaining ovarian function through various mechanisms such as antioxidant stress, regulating autophagy and apoptosis, anti-inflammatory and immunomodulation, and telomere protection. However, from laboratory research to clinical application, it still faces multiple challenges such as bioavailability, long-term safety and individual differences. Future research needs to further optimize the delivery system, carry out long-term clinical trials, and explore individualized treatment strategies to promote the clinical transformation and application of anti-female reproductive aging molecules.
