Impact of remimazolam besylate combined with sufentanil on cognition and inflammatory factor levels in elderly patients undergoing laparoscopic inguinal hernia surgery
- VernacularTitle:苯磺酸瑞马唑仑复合舒芬太尼对老年患者腹腔镜腹股沟疝手术后认知功能和炎症因子水平的影响
- Author:
Wei WANG
1
;
Jun SHI
1
;
Ying WANG
1
;
Guangjie FAN
1
Author Information
- Publication Type:Journal Article
- Keywords: remimazolam besylate; propofol; sufentanil; elderly patients; laparoscopic inguinal hernia surgery; inflammatory factors; postoperative cognitive function; stress indicators
- From: China Journal of Endoscopy 2025;31(1):57-64
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the impact of remimazolam besylate combined with sufentanil for postoperative cognitive function and inflammatory factor levels in elderly patients underwent laparoscopic inguinal hernia surgery.Methods 100 elderly patients who underwent laparoscopic inguinal hernia surgery were selected and included from July 2022 to December 2023.Divide into a study group(n=50,remimazolam besylate combined with sufentanil anesthesia)and a control group(n=50,propofol combined with sufentanil anesthesia)using a random number table method.Compare the mean arterial pressure(MAP),heart rate(HR),plasma stress indicators[adrenaline(AD),norepinephrine(NE)and cortisol(Cor)],serum inflammatory factors[interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)],the mini mental state examination(MMSE)scale,Montreal cognitive assessment(MoCA)scale,visual analogue scale(VAS),Ramsay sedation scale,and adverse reactions between the two groups.Results There were differences in MAP and HR levels between the two groups in terms of time,inter group,and interaction effects(P＜0.05).At 24 h after surgery,compared with the control group,the study group had lower levels of AD,NE,Cor,IL-6,and TNF-α,higher levels of IL-10,MoCA and MMSE scales,the differences were statistically significant(P＜0.05).At 12 and 24 h after surgery,compared with the control group,the study group had lower VAS and higher Ramsay scales,the differences were statistically significant(P＜0.05).The additional dose of sufentanil in the study group was(7.44±1.35)μg,which was lower than that in the control group(8.25±1.43)μg,with statistical difference(t=2.91,P=0.004).There was no difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Remimazolam+sufentanil in elderly patients with laparoscopic inguinal hernia surgery can improve their cognitive function by reducing inflammation and with high safety.It is worthy of clinical application.
