Observation on the clinical efficacy of Zishen Yutai Pill in frozen-thawed embryo transfer after repeated embryo implantation failures
10.3760/cma.j.cn101441-20240911-00336
- VernacularTitle:滋肾育胎丸在反复种植失败患者冻融胚胎移植中的临床疗效观察
- Author:
Yuanmei LI
1
;
Rui SI
;
Xiuqing ZHANG
;
Haiyan LI
;
Ye ZHENG
;
Xu HAN
;
Huidan WANG
;
Xiufang LI
Author Information
1. 山东大学妇儿与生殖健康研究院 山东大学附属生殖医院女性生殖科，济南 250012
- Publication Type:Journal Article
- Keywords:
Pregnancy outcome;
Zishen Yutai Pill;
Frozen-thawed embryo transfer;
Repeated implantation failure
- From:
Chinese Journal of Reproduction and Contraception
2025;45(3):240-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical application effect of Zishen Yutai Pill in patients with repeated implantation failure (RIF) undergoing frozen-thawed embryo transfer (FET) cycles.Methods:A retrospective case-control study was conducted, selecting 744 cycles of patients with RIF at the Department of Female Reproductive Medicine,State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University from October 2017 to April 2023. The patients were divided into experimental group (treated with Zishen Yutai Pill, n=279) and control group (treated without Zishen Yutai Pill, n=465) based on whether Zishen Yutai Pill was added to luteal support. The pregnancy outcomes between the two groups were compared. Based on the different endometrial preparation protocols in the FET cycles, the patients were used down-regulation protocol ( n=271) or non-down-regulation protocol ( n=473). The pregnancy outcomes of the two groups in each protocol were compared. Results:There were no statistically significant differences between the two groups in terms of biochemical pregnancy rate, clinical pregnancy rate, embryo implantation rate, early miscarriage rate, late miscarriage rate, and live birth rate (all P>0.05). However, the biochemical pregnancy rate [69.0% (58/84)], clinical pregnancy rate [59.5% (50/84)], and embryo implantation rate [59.4% (57/96)] in the experimental group of the down-regulated protocol were significantly higher than those in control group [56.1% (105/187), P=0.045; 46.5% (87/187), P=0.048; 44.9% (92/205), P=0.019], with statistically significant differences. In the non-down-regulated protocol, there were no statistically significant differences in pregnancy outcomes between the two groups (all P>0.05). Conclusion:In the FET down-regulated protocol, Zishen Yutai Pill can significantly improve the clinical pregnancy rate and the embryo implantation rate in patients with RIF, thereby improving pregnancy outcomes.
