Research progress on the regulation of growth and metabolism of Clostri-dioides difficile by nutrients and gut microbes
10.12138/j.issn.1671-9638.20252422
- VernacularTitle:营养素与肠道微生物调控艰难梭菌生长代谢的研究进展
- Author:
Weigang WANG
1
;
Qiuyue HUO
1
;
Jianhong ZHAO
1
;
Jiafeng ZHAO
1
Author Information
1. 河北医科大学第二医院河北省临床检验中心,河北石家庄 050000;河北省精准医学诊断与质量控制技术创新中心,河北 石家庄 050000;医学微生物组与临床转化河北省工程研究中心,河北 石家庄 050000
- Publication Type:Journal Article
- Keywords:
Clostridioides difficile infection;
gut microbe;
metabolic pathway;
nutrient
- From:
Chinese Journal of Infection Control
2025;24(11):1663-1670
- CountryChina
- Language:Chinese
-
Abstract:
Clostridioides difficile infection(CDI)is the leading cause of hospital-acquired diarrhea and has be-come a major challenge in the global public health field.In recent years,it has been found that nutrients and gut mi-crobes play key roles in regulating growth,metabolic activity,and virulence expression of Clostridioides difficile.However,current research focuses on the independent effects of a single nutrient or gut microbe,systematic under-standing on the interactions between them is still lacking.This paper reviews the specific effect of different nutrients on Clostridioides difficile,explores how other gut microbes inhibit the growth of Clostridioides difficile by com-peting or metabolizing nutrients.In addition,this paper also discusses the application of emerging technologies in CDI research and their potentiality in clinical intervention strategies.Future research needs to integrate multi-omics data and artificial intelligence analysis,deeply analyze the complex interactive network of nutrient-microbe-host,and provide new ideas for precise prevention and treatment of CDI.
