Research progress in neoadjuvant therapy for locally advanced rectal cancer
- VernacularTitle:局部进展期直肠癌新辅助治疗的研究进展
- Author:
Yu-fei HU
1
;
Yue SUN
;
Yan FU
;
Heng LI
Author Information
- Publication Type:Journal Article
- Keywords: rectal cancer; locally advanced stage; neoadjuvant therapy; neoadjuvant chemoradiotherapy
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(2):178-182
- CountryChina
- Language:Chinese
- Abstract: Rectal cancer is one of the most common gastrointestinal malignant tumors,and patients with early rectal cancer can achieve radical tumor resection by surgical treatment alone,while most patients with rectal cancer are in the locally advanced stage when admitted to hospital.For this group of people,it is difficult to obtain a good prognosis through surgical treatment alone,and interventional chemoradio-therapy before surgery is of important clinical significance.A large number of clinical studies have proved that preoperative neoadjuvant therapy can effectively reduce tumor stage,increase pathological complete response(pCR)rate,thereby greatly improving the prognosis of patients.At present,the core methods of neoadjuvant therapy for locally advanced rectal cancer are radiotherapy and chemotherapy,as well as the emerging targeted therapy and immunotherapy,while the optimal combination order of various treatments remains in dispute.This article summarizes various neoadjuvant therapy regimens in recent years,in order to provide evidence for the multidisciplinary and comprehensive treatment of rectal cancer.
