Advances in the regulatory mechanisms of the PI3K/Akt signaling pathway in bac-terial infections
10.16303/j.cnki.1005-4545.2025.11.31
- VernacularTitle:PI3K/Akt信号通路在细菌性感染中调控机制的研究进展
- Author:
Nan HU
1
;
Yixi SUN
1
;
Xiaowei YANG
1
Author Information
1. 西南大学动物医学院,重庆4024602
- Publication Type:Journal Article
- Keywords:
PI3K/Akt signaling pathway;
bacterial infection;
host-pathogen interaction;
targeted therapy
- From:
Chinese Journal of Veterinary Science
2025;45(11):2557-2568
- CountryChina
- Language:Chinese
-
Abstract:
The PI3K/Akt signaling pathway,a critical intracellular regulatory network,plays a piv-otal role in diverse physiological processes,including cell survival,proliferation,metabolism,and immune regulation.Current research has transitioned from elucidating fundamental molecular mechanisms to exploring novel dimensions within the host-pathogen interaction regulatory net-work.This shift emphasizes uncovering molecular strategies employed by pathogens to evade host immune clearance by hijacking or inhibiting this pathway,as well as developing targeted anti-infec-tion therapies specific to this pathway.This article delineates the components and activation mecha-nisms of the PI3K/Akt pathway and reviews its specific roles in mediating immune defense,im-mune evasion,and host tissue damage during bacterial infections.Furthermore,it evaluates the po-tential of targeting this pathway as a therapeutic strategy for infectious diseases.By synthesizing existing research and providing future perspectives,this review aims to advance the understanding of bacterial infection pathogenesis and inform the development of non-antibiotic therapies targeting host signaling pathways.
