Advances in day 4 embryo transfer for in vitro fertilization
10.3760/cma.j.cn101441-20250402-00165
- VernacularTitle:体外受精第4天胚胎移植的研究进展
- Author:
Fangfang DAI
1
;
Bo ZHENG
;
Yasong GENG
;
Linlin TAO
;
Haoyang DAI
;
Shusong WANG
Author Information
1. 邢台美和生殖与遗传医院生殖医学中心 邢台市生殖医学重点实验室，邢台 054000
- Publication Type:Journal Article
- Keywords:
Morula;
Embryo compaction;
Day 4 embryo transfer;
Day 4 embryo grading;
Endometrial implantation window
- From:
Chinese Journal of Reproduction and Contraception
2025;45(9):954-959
- CountryChina
- Language:Chinese
-
Abstract:
With advancements in in vitro culture techniques, the morula has emerged as a promising candidate for selective embryo transfer due to its critical compaction phase. The compaction process involves not only structural reorganization but also complex intercellular signaling mechanisms that significantly influence embryonic developmental potential and cellular fate determination. Clinical data reveal comparable live birth rates between day 4 morula transfers and day 5 blastocyst transfers, coupled with reduced in vitro culture duration. However, challenges persist regarding standardized evaluation criteria and long-term safety confirmation. Current morphological assessment methods exhibit inherent subjectivity, while emerging technologies integrating genetic screening, metabolic analysis, and time-lapse imaging show potential for enhanced selection accuracy. Personalized synchronization assessments, including endometrial receptivity analysis, may further optimize transfer protocols. This study focuses on day 4 embryo transfer, systematically reviewing its embryonic development processes, evaluation protocols, comparative outcomes of transferred embryos, and research advances in frozen-thawed embryo transfer. The study aims to deepen scientific understanding of day 4 embryo transfer and promote its adoption as a critical option in personalized reproductive medicine, thereby enhancing clinical success rates and safety.
