Research progress of apoptotic events during preimplantation embryonic development
10.3760/cma.j.cn101441-20241114-00418
- VernacularTitle:着床前胚胎发育过程中细胞凋亡的研究进展
- Author:
Yutong WANG
1
;
Jin HUANG
1
Author Information
1. 北京大学第三医院妇产科生殖医学中心 女性生育力促进全国重点实验室 国家妇产疾病临床医学研究中心（北京大学第三医院）辅助生殖教育部重点实验室（北京大学）生殖内分泌与辅助生殖技术北京市重点实验室，北京100191
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Apoptosis-inducing factors;
Apoptosis-regulating proteins;
Early embryonic development
- From:
Chinese Journal of Reproduction and Contraception
2025;45(4):428-432
- CountryChina
- Language:Chinese
-
Abstract:
Programmed cell death or apoptosis is a common biological phenomenon. Although early embryonic development is dominated by cell division and proliferation, there are also apoptotic events. The disturbance of apoptosis may lead to abnormal or stagnant embryo development, or even embryo death. Apoptosis is characterized by typical cell changes such as membrane blistering, chromatin clotting, and DNA breakage. It involves many membrane receptors (e.g., Fas, TNFR) and a series of signal transduction steps, and leads to the activation of many cysteine proteases. Preimplantation embryo apoptosis can be induced by various internal and external factors. Internal factors such as DNA damage, endoplasmic reticulum stress, mitochondrial dysfunction; external factors such as activation of apoptosis-related receptors, stimulation of various extracellular factors, etc. Understanding the influence of apoptosis on early embryonic development and its mechanism is helpful to further understand the embryonic development mechanism, and can optimize the embryo culture conditions and reduce the negative effects of apoptosis, so as to provide guidance for clinical practice. Therefore, this article reviews the apoptotic events and their role in early preimplantation embryonic development.
