Research progress on the effects and mechanisms of fetal growth restriction induced by PM 2.5 exposure
10.3760/cma.j.cn101441-20241021-00382
- VernacularTitle:PM 2.5暴露对胎儿生长受限的影响及机制研究进展
- Author:
Shimin TAO
1
;
Weihua LI
;
Yanyi XU
Author Information
1. 国家卫生健康委生育调节药械重点实验室 上海生殖健康药具工程技术研究中心 上海市生物医药技术研究院 复旦大学药学院，上海 200237
- Publication Type:Journal Article
- Keywords:
Air pollution;
Pregnancy complications;
Molecular mechanisms;
Inflammatory response;
Epigenetic modifications
- From:
Chinese Journal of Reproduction and Contraception
2025;45(4):421-427
- CountryChina
- Language:Chinese
-
Abstract:
The adverse effects of fine particulate matter (PM 2.5) on human health have become a major global public health concern. Pregnant women and fetuses, as susceptible populations, are more vulnerable to the threat of PM 2.5 pollution. Increasing studies indicate that PM 2.5 exposure is an important risk factor of fetal growth restriction (FGR), and oxidative stress, inflammatory response, endocrine disorders, epigenetic modifications, autophagic abnormalities, and gut microbiota dysbiosis may be the biological mechanisms underlying PM 2.5-induced FGR. This study offers insights for the development of targeted preventive and therapeutic methods for FGR caused by PM 2.5.
