Research advances in the immune microenvironment in polycystic ovary syndrome
10.3760/cma.j.cn101441-20250322-00138
- VernacularTitle:免疫微环境在多囊卵巢综合征中的研究进展
- Author:
Zhaokang QI
1
;
Tingting WANG
;
Jinxin REN
;
Jinlong SUN
;
Yuan LI
;
Yi YU
;
Fang LIAN
Author Information
1. 山东中医药大学第一临床医学院，济南 250035
- Publication Type:Journal Article
- Keywords:
Immune microenvironment;
Polycystic ovary syndrome;
Innate immunity;
Adaptive immunity;
Gut microbiota
- From:
Chinese Journal of Reproduction and Contraception
2025;45(9):967-972
- CountryChina
- Language:Chinese
-
Abstract:
The immune microenvironment plays a pivotal role in maintaining ovarian homeostasis. Polycystic ovary syndrome (PCOS), a common endocrine and metabolic disorder, is closely associated with immune microenvironment imbalance. This review systematically describes the dysregulation of innate immune cells (e.g., macrophages, natural killer cells and dendritic cells) and adaptive immune cells (e.g., Th1, Th2, Treg and Th17) in PCOS, highlighting their impacts on ovarian function, insulin resistance, and hyperandrogenemia. These findings underscore the central role of immune microenvironment disturbances in PCOS pathogenesis. Additionally, the association between gut microbiota dysbiosis and PCOS is explored, emphasizing how gut microbiota influences metabolic byproducts and hormonal levels to contribute to PCOS development. Furthermore, therapeutic strategies targeting immune microenvironment imbalance such as modulating macrophage polarization, restoring Th1/Th2 and Th17/Treg balance, and ameliorating gut microbiota dysbiosis are discussed, offering novel insights for PCOS immunotherapy. In conclusion, this review comprehensively analyzes the pathogenesis of PCOS from the perspective of the immune microenvironment, aiming to provide a theoretical foundation and reference for future research and clinical practice.
