Cardiovascular Magnetic Resonance Imaging for Assessing the Impact of Diabetes on Left Ventricular Remodeling and Strain in Hypertrophic Cardiomyopathy
10.3969/j.issn.1005-5185.2025.11.012
- VernacularTitle:心血管磁共振评估糖尿病对肥厚型心肌病患者左心室重构及应变的影响
- Author:
Zhi YANG
1
;
Bing FU
1
;
Miao WEN
1
;
Shuyue PAN
1
;
Tianyue ZHANG
1
;
Yitian LONG
1
;
Xue MENG
1
Author Information
1. 成都市第五人民医院放射科,四川 成都 611130
- Publication Type:Journal Article
- Keywords:
Cardiomyopathy,hypertrophic;
Diabetes mellitus;
Cardiovascular magnetic resonance;
Late gadolinium enhancement;
Strain;
Ventricular function,left
- From:
Chinese Journal of Medical Imaging
2025;33(11):1208-1214
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To compare the clinical and cardiovascular magnetic resonance(CMR)characteristics of hypertrophic cardiomyopathy(HCM)with and without diabetes mellitus,and to investigate the effect of diabetes mellitus on left ventricular remodeling in HCM patients.Materials and Methods A total of 96 HCM patients diagnosed with CMR in Chengdu Fifth People's Hospital from January 2021 to March 2023,retrospectively.They were divided into HCM with diabetes mellitus group(n=22)and HCM without diabetes mellitus group(n=74)according to whether they had diabetes mellitus.The clinical baseline and CMR data of HCM patients were analyzed,and left ventricular function and strain were compared between the two groups.Results The HCM group with diabetes mellitus was observed to have a significantly higher left ventricular mass index compared to HCM without diabetes mellitus group[(1.33±0.50)g/ml vs.(1.10±0.23)g/ml;t=3.002,P=0.003],along with a significantly lower left ventricular global circumferential strain[-19.69(-21.82,-17.06)%vs.-16.33(-20.84,-13.86)%;Z=543.000,P<0.05]and global longitudinal strain[(-8.69±3.94)%vs.(-10.74±3.62)%;t=2.227,P<0.05)].Furthermore,diabetes mellitus was identified as an independent factor associated with an increased left ventricular mass index(β=0.330,P<0.05)by multivariate linear regression analysis.Conclusion In patients with HCM,diabetes mellitus is independently associated with left ventricular remodeling.The global circumferential strain and longitudinal strain of HCM patients with diabetes mellitus decreases significantly,suggesting that diabetes mellitus has a significant impact on left ventricular strain in HCM patients.
