Short-Term Efficacy of CalliSpheres? Drug-Eluting Beads for Embolization in the Treatment of Non-Small Cell Lung Cancer
10.3969/j.issn.1005-5185.2025.11.008
- VernacularTitle:载药微球化疗栓塞术治疗非小细胞肺癌的短期疗效
- Author:
Yuanbiao LUO
1
;
Zhou ZHOU
;
Xiafen HE
;
Jiangtao WU
;
Chengsong ZHENG
;
Qingdao SU
Author Information
1. 普洱市第二人民医院放射科,云南 普洱 665000
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
CalliSpheres? drug-eluting bead;
Embolization,therapeutic;
Angiography,digital subtraction;
Disease remission rate;
Short-term efficacy
- From:
Chinese Journal of Medical Imaging
2025;33(11):1186-1190
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the short-term efficacy of CalliSpheres? drug-eluting beads for embolization in the treatment of non-small lung cancer compared with bronchial artery chemoembolization and systemic vein chemotherapy.Materials and Methods A retrospective analysis was performed on 78 patients with pathologically confirmed non-small cell lung cancer from the First Affiliated Hospital of Dali University from March 2016 to September 2018.The patients were assigned to three groups(n=26 each):an observation group receiving CalliSpheres? drug-eluting bead embolization,a control group receiving bronchial arterial chemoembolization,and a conventional group receiving systemic intravenous chemotherapy.In both the observation and control groups,after the tumor-feeding arteries were identified by bronchial arteriography,a coaxial microcatheter was superselectively advanced into these arteries.Chemotherapeutic agents were then infused separately through each individual feeding artery.The observation group underwent embolization using drug-eluting microspheres,whereas the control group underwent embolization with blank microspheres.The conventional group was treated with intravenous chemotherapy.The objective response rates at 2 months post-procedure were compared among the three groups.Results The objective response rates at 2 months post-procedure were as follows:observation group,84.62%;control group,57.69%;conventional group,26.92%.The observation group showed a significantly superior objective response rate relative to the control group and the conventional group(χ2=4.591,17.541,P<0.05).Additionally,the objective response rate in the control group was significantly higher than that in the conventional group(χ2=5.042,P=0.025).Conclusion For non-small cell lung cancer,CalliSpheres? drug-eluting bead embolization provides significantly better short-term clinical efficacy than both bronchial arterial chemoembolization and systemic intravenous chemotherapy.Bronchial arterial chemoembolization itself is more effective than systemic intravenous chemotherapy.
