Research progress on mechanisms and clinical management of comorbid constipation in children with autism spectrum disorder
10.7499/j.issn.1008-8830.2506077
- VernacularTitle:孤独症谱系障碍儿童共患便秘的机制及临床管理的研究进展
- Author:
Jie-Jie DING
1
;
Dong-Yue DU
;
Ping LI
Author Information
1. 吉林大学第二医院发育儿科,吉林 长春 130041
- Publication Type:Journal Article
- Keywords:
Autism spectrum disorder;
Constipation;
Gut microbiota;
Intestinal permeability;
Sensory abnormality;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(12):1549-1555
- CountryChina
- Language:Chinese
-
Abstract:
Children with autism spectrum disorder(ASD)frequently have comorbid gastrointestinal problems,with constipation being the most prevalent.The onset and severity of constipation are closely related to the core symptoms of ASD,and improving constipation can alleviate these core symptoms.However,the mechanisms underlying comorbid constipation in ASD remain unclear.Multidisciplinary assessment is the foundation of clinical management for comorbid constipation in ASD.Targeted pharmacological therapy,dietary interventions,gut microbiota modulation,and complementary and alternative medicine interventions can be chosen for personalized treatment.This review summarizes the mechanisms,assessment,and clinical management of comorbid constipation in ASD and aims to provide a reference for comprehensive interventions in ASD.
