Role of ferroptosis in myocardial ischemia-reperfusion injury
10.20039/j.cnki.1007-3949.2024.12.012
- VernacularTitle:铁死亡在心肌缺血再灌注损伤中的作用
- Author:
Yifang HAO
1
;
Ting LI
;
Fengnan NIU
;
Yumeng REN
;
Shengyao LI
Author Information
1. 山西中医药大学,山西省太原市 030000
- Publication Type:Journal Article
- Keywords:
ferroptosis;
myocardial ischemia-reperfusion injury;
signaling pathway
- From:
Chinese Journal of Arteriosclerosis
2024;32(12):1097-1104
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia-reperfusion injury(MIRI)is one of the reasons for the high mortality in patients with acute myocardial infarction after percutaneous coronary intervention,which is regulated by several cell death pathways including apoptosis,autophagy,and pyroptosis.Recently,it has been found that ferroptosis,a unique programmed cell death,appears to be a therapeutic target for MIRI.However,the mechanisms remain incompletely elucidated.This re-view summarizes the latest research progress on the role of ferroptosis in MIRI,including mitochondrial dysfunction,endo-plasmic reticulum stress(ERS),oxidative stress,calcium overload,epigenetic modification,apoptosis,autophagy,etc.Moreover,the signaling pathways between ferroptosis and MIRI are elaborated,which will provide new insights for the prevention and treatment of MIRI.
