Cuproptosis in relation to MIRI and heart failure
10.20039/j.cnki.1007-3949.2024.12.010
- VernacularTitle:铜死亡与MIRI和心力衰竭的关系
- Author:
Xiaoxiao LIU
1
;
Hongyu LI
1
;
Yaowei ZHAO
1
;
Xiyuan MA
1
;
Chunyang DONG
1
;
Qiang TANG
1
Author Information
1. 黑龙江中医药大学,黑龙江省哈尔滨市 150006
- Publication Type:Journal Article
- Keywords:
copper;
cardioprotection;
cuproptosis;
myocardial ischemia-reperfusion injury;
heart failure
- From:
Chinese Journal of Arteriosclerosis
2024;32(12):1082-1088
- CountryChina
- Language:Chinese
-
Abstract:
Timely restoration of blood supply after myocardial infarction is crucial for saving the infarcted myocardi-um.So far,the most effective method is to restore myocardial oxygenation and coronary blood flow through coronary inter-ventional therapy.However,reperfusion may also lead to greater heart damage due to the reintroduction of molecular oxy-gen.New treatments are needed to protect the heart from myocardial ischemia-reperfusion injury(MIRI)to improve clini-cal outcomes in patients with acute myocardial infarction and heart failure(HF).A deeper understanding of the mecha-nisms of MIRI and the search for new treatments could provide key evidence to mitigate myocardial damage and improve pa-tient survival.At present,it has been found that copper,as a trace element in human body,can have a significant pro-tective effect on MIRI.Copper can reduce apoptosis in cardiomyocytes,that is,control the self-destruction process of cell,so as to reduce the degree of myocardial injury.However,the potential relationship between abnormal copper ion metabolism as well as cuproptosis and MIRI as well as HF has not been explored.In this review,we focus on potential therapeutic strategies for MIRI and understand the metabolic pathways of copper in the human body,so as to provide more options and hope for the treatment of cardiovascular diseases.
