Nasopharyngeal carcinoma in children:clinical analysis of 6 cases and literature review
10.7499/j.issn.1008-8830.2508083
- VernacularTitle:6例儿童鼻咽癌临床分析并文献复习
- Author:
Mei-Ling TANG
1
;
Wei-Ling ZHANG
1
;
Yi-Zhuo WANG
1
;
Yi ZHANG
1
Author Information
1. 首都医科大学附属北京同仁医院儿科,北京 100176
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal carcinoma;
Clinical feature;
Treatment;
Prognosis;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2025;27(12):1520-1525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics,imaging findings,pathological features,treatment methods,and prognosis of nasopharyngeal carcinoma in children.Methods The clinical data of 6 children(<18 years)with nasopharyngeal carcinoma admitted to the Department of Pediatrics,Beijing Tongren Hospital from March 2021 to February 2025 were retrospectively reviewed,and outcomes were followed up.Results All 6 patients were male.Age at onset ranged from 11 to 15 years,with a median of 12.5 years.The interval from onset to diagnosis was 1-6 months.The main clinical symptoms were cervical mass(4 cases,67%)and headache(3 cases,50%);some patients also had nasal congestion and rhinorrhea,epistaxis,or limited mouth opening.TNM staging was stage III in 4 cases and stage IVa in 2 cases.All patients had non-keratinizing undifferentiated nasopharyngeal carcinoma on pathology.Treatments included radiotherapy,chemotherapy,surgery,targeted therapy,and immunotherapy.By July 1,2025,after comprehensive treatment,5 patients(83%)achieved complete remission,and 1 patient(17%)experienced recurrence and progression and died.Conclusions Comprehensive treatment based on combined radiotherapy and chemotherapy is the mainstay for childhood nasopharyngeal carcinoma,overall prognosis is favorable,and long-term follow-up is required.Molecular targeted therapy and immunotherapy are expected to improve the prognosis of advanced nasopharyngeal carcinoma and require further research for validation.
