MRI Characteristics of Central Nervous System Candidiasis in Infants Children with Normal Immunity
10.3969/j.issn.1005-5185.2025.11.011
- VernacularTitle:免疫正常婴幼儿中枢神经系统念珠菌病的MRI特征
- Author:
Yingzi GAO
1
;
Shuangfeng YANG
1
;
Hua CHENG
1
;
Yun PENG
1
Author Information
1. 国家儿童医学中心,首都医科大学附属北京儿童医院影像中心,北京 100045
- Publication Type:Journal Article
- Keywords:
Central nervous system;
Candidiasis;
Magnetic resonance imaging;
Candida colonization;
Infants;
Normal immunity
- From:
Chinese Journal of Medical Imaging
2025;33(11):1203-1207
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinical and imaging characteristics of central nervous system candidiasis due to Candida albicans in immunocompetent infants children.Materials and Methods A retrospective analysis was conducted on immunocompetent children with central nervous system candidiasis diagnosed at Beijing Children's Hospital,Capital Medical University from October 2012 to October 2022,and their clinical and MRI characteristics were analyzed.Results Among the 26 enrolled children,88.5%(23 cases)were under one year old,and 88.5%(23 cases)had high-risk factors.Premature birth was the most common high-risk factor(16 cases,61.5%).All 26 cases had positive MRI examinations,with the main manifestations being meningeal thickening and enhancement(25 cases,96.2%),57.7%(15 cases)involving the skull base meninges,23.1%(six cases)involving the cranial nerves,intracranial localized granulomas(16 cases,61.5%),hydrocephalus(14 cases,53.8%),cerebral infarction(four cases,15.4%),subdural effusion(six cases,23.1%)and cerebral abscess(two cases,7.7%);13 cases of magnetic resonance angiography and magnetic resonance venography examinations were performed,and 10 cases of magnetic resonance angiography abnormalities were found,mainly due to thinning,narrowing or reduced branches of the arterial trunk,and one case of magnetic resonance venography transverse sinus thrombosis.Conclusion Central nervous system candidiasis mostly exists in children younger than one year old.MR imaging shows a more characteristic invasion of the skull base,often causing enhancement of the skull base meninges and cranial nerves,as well as localized granulomas and hydrocephalus.Imaging examination is of great significance for early diagnosis.
