Impact of transferring vitrified-thawed non-re-expanded blastocysts on pregnancy and neonatal outcomes: a retrospective cohort study based on propensity score matching
10.3760/cma.j.cn101441-20250207-00050
- VernacularTitle:玻璃化解冻后移植未扩张囊胚对妊娠及新生儿结局的影响：基于倾向性评分匹配的回顾性队列研究
- Author:
Jie ZHU
1
;
Huiqun YIN
1
;
Cunli WANG
1
;
Kang LUAN
1
;
Yan WU
1
;
Feng NI
1
Author Information
1. 中国人民解放军联勤保障部队第九〇一医院生殖医学中心，合肥 230031
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Blastocyst transfer;
Vitrification;
Re-expansion;
Propensity score matching
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):696-701
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of the transfer of blastocysts that have not re-expanded after 2-4 h of thawing on pregnancy and neonatal outcomes.Methods:A retrospective cohort study was performed to analyze the clinical data from 2 428 vitrified frozen-thawed single blastocyst transfer cycles at the Reproductive Medicine Center of the 901st Hospital of the Joint Logistics Support Force of PLA between January 2015 and March 2024. Based on the re-expansion status of the blastocoel cavity after thawing, the cycles were divided into group A (110 non-re-expanded) and group B (2 318 re-expanded). After propensity score matching, there were 109 cycles in each group. Pregnancy and neonatal outcomes between the two groups were compared.Results:Before propensity score matching, there were statistical differences in percentage of good-quality blastocyst transfer, percentage of degree 4 blastocyst, percentage of endometriosis and others in reasons for infertility between the two groups (all P<0.05). After propensity score matching, there were no statistical differences in baseline characteristics between the two groups (all P>0.05). The clinical pregnancy rate [27.52% (30/109)], the ongoing pregnancy rate [21.10% (23/109)] and the live birth rate [19.27% (21/109)] in group A were all significantly lower than those in group B [61.47% (67/109), 51.38% (56/109), 47.70% (52/109), all P<0.001]. Neonatal outcomes showed no statistically significant differences between the two groups in terms of birth weight, neonatal length, malformation rate, monozygotic twin rate and male neonatal rate (all P>0.05). Conclusion:Transfer of non-re-expanded blastocysts after thawing may reduce clinical pregnancy rate but does not negatively affect neonatal outcomes.
