Evaluation of Multimodal MRI in the Outcome of Traumatic Brain Injury in Rats After Treatment
10.3969/j.issn.1005-5185.2025.11.010
- VernacularTitle:多模态MRI在大鼠创伤性脑损伤治疗后转归中的评价
- Author:
Yiming YUE
1
;
Lingfei WANG
;
Wen LI
;
Wenjun XUE
Author Information
1. 南阳医学高等专科学校第一附属医院磁共振室,河南 南阳 473007
- Publication Type:Journal Article
- Keywords:
Brain injuries,traumatic;
Magnetic resonance imaging;
Diffusion weighted imaging;
Diffusion tensor imaging;
Diffusion kurtosis imaging;
Hyperbaric oxygenation;
Conversion;
Rats,Sprague-Dawley;
Experimental study
- From:
Chinese Journal of Medical Imaging
2025;33(11):1196-1202
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the evaluation value of multimodal MRI in the outcome of traumatic brain injury(TBI)in rats.Materials and Methods A total of 30 TBI rat models were established,randomly divided into an untreated TBI group and a TBI treated group(hyperbaric oxygen)with 15 rats each.The Sham group with 15 rats was used as a healthy control,and the brain injury status of the rats was evaluated at 1 d,3 d,7 d,14 d and 28 d of modeling.Multimodal MRI was performed in parallel,and coronary T2WI,diffusion weighted imaging,diffusion kurtosis imaging and diffusion tensor imaging sequences were routinely scanned.The correlation between rat neurological function scores and various sequence parameters were analyzed,as well as multimodal MRI and the outcome of brain injury after TBI treatment in rats.Results The neurological function score and average kurtosis of the TBI treatment group were lower than those of the TBI untreated group(P<0.05).The apparent diffusion coefficient and anisotropy score of the TBI treatment group were higher than those of the TBI untreated group(P<0.05).The diffusion weighted imaging parameter apparent diffusion coefficient value and diffusion tensor imaging parameter fraction anisotropy value were negatively correlated with the degree of brain injury in TBI rats after 28 days of treatment(r=-0.675,-0.611,P<0.05),while the diffusion kurtosis imaging parameter mean kurtosis value was positively correlated with the degree of brain injury in TBI rats after 28 days of treatment(r=0.623,P<0.05).Conclusion Multimodal MRI can effectively evaluate the brain injury status of TBI rats and provide valuable information for dynamic evaluation after hyperbaric oxygen therapy for TBI,with high evaluation value in treatment outcomes.
