Gut microbiota dysbiosis and male fertility: research progress on mechanisms and modulation strategies
10.3760/cma.j.cn101441-20250307-00112
- VernacularTitle:肠道菌群失调与男性生育力：机制和调节策略的研究进展
- Author:
Siyi XIA
1
;
Yuqin SHI
1
;
Ling ZHANG
1
Author Information
1. 武汉科技大学医学部公共卫生学院 湖北省职业危害识别与控制重点实验室，武汉 430065
- Publication Type:Journal Article
- Keywords:
Inflammation;
Immunity;
Diet;
Lifestyle;
Hormones;
Gut microbiota;
Male fertility
- From:
Chinese Journal of Reproduction and Contraception
2025;45(6):564-570
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the relationship between gut microbiota and various systemic diseases has been increasingly elucidated, and its role in the male reproductive system has attracted growing attention. The gut microbiota, a complex and vast microbial community residing in the human intestine, is involved in the regulation of male fertility through multiple mechanisms, including modulation of sex hormone levels, inflammatory responses, microbial metabolites, immune regulation, and endocrine signaling pathways. Furthermore, dietary interventions, lifestyle modifications, and medical therapies can improve male fertility by restoring gut microbial balance. Exploring the intricate relationship between gut microbiota and male fertility holds significant scientific and clinical value. This review summarizes the current research progress on the mechanisms underlying the relationship between gut microbiota dysbiosis and male fertility, and discusses the potential of interventions targeting gut microbiota dysbiosis as a novel strategy to improve reproductive outcomes.
