Amide Proton Transfer Combined with Diffusion Kurtosis Imaging in the Differential Diagnosis of Prostate Carcinoma and Benign Prostatic Hyperplasia
10.3969/j.issn.1005-5185.2025.11.017
- VernacularTitle:酰胺质子转移成像联合扩散峰度成像鉴别前列腺癌及前列腺增生
- Author:
Huijia YIN
1
;
Xuekun LI
1
;
Ruifang YAN
1
;
Dongming HAN
1
Author Information
1. 新乡医学院第一附属医院磁共振科,河南 卫辉 453100
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Prostatic hyperplasia;
Magnetic resonance imaging;
Diffusion kurtosis imaging;
Amide proton transfer imaging;
Diagnosis,differential
- From:
Chinese Journal of Medical Imaging
2025;33(11):1235-1240
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of amide proton transfer(APT)imaging combined with diffusion kurtosis imaging(DKI)in the differential diagnosis of prostate carcinoma and benign prostatic hyperplasia.Materials and Methods A retrospective analysis was conducted on 120 patients who underwent multi-parameter prostate MRI and pathological biopsy at the First Affiliated Hospital of Xinxiang Medical University from January 2020 to August 2021,including 66 cases of benign prostatic hyperplasia and 54 cases of prostate carcinoma.The parameters of APT imaging and DKI,including magnetization transfer ratio asymmetry(MTRasym),mean kurtosis(MK),mean diffusion coefficient(MD)and fraction anisotropy were measured,and the parameters between the two groups were compared and analyzed.The receiver operating characteristic curve and Delong test were used to analyze the efficacy of each parameter,APT or DKI sequence alone and their combined diagnosis,and the correlation among the parameters was analyzed.Results Compared with the benign prostatic hyperplasia group,the MTRasym,MK and fraction anisotropy of the prostate carcinoma group were significantly higher,while the MD was significantly lower,with statistical significance(t=8.23,12.53,2.20,-11.12,all P<0.05).The areas under the curve for the above parameters were 0.852,0.933,0.615 and 0.910,respectively.The diagnostic efficacy of APT combined with DKI for differentiating prostate carcinoma from benign prostatic hyperplasia is numerically higher than that of APT alone or DKI alone,with the areas under the curve being 0.994,0.988 and 0.852,respectively,as well as a sensitivity of 96.30%and a specificity of 98.48%.There was a statistically significant difference in efficacy between the APT+DKI combined approach and APT alone(Z=4.387,P<0.05),while no statistically significant difference exists between the combined approach and DKI alone(Z=1.375,P>0.05).MTRasym was positively correlated with MK(r=0.45,P<0.001).MD was negatively correlated with MTRasym and MK(r=-0.439,-0.500,both P<0.001).Conclusion The parameters MTRasym,MK and MD of APT and DKI have relatively high value in distinguishing prostate carcinoma from benign prostatic hyperplasia,and the combined diagnostic efficiency of the two sequences tends to increase,with some parameters showing correlation.
