Exploration of Heat Clearing Herbs with Anti-inflammatory and Anti-tumor Effects Based on the Traditional Chinese Medicine Pathogenic Factors of Pancreatitis-induced Pancreatic Ductal Adenocarcinoma
- VernacularTitle:基于胰腺炎-癌转化中医病机要素挖掘兼具抗炎抗肿瘤功效的清热类中药
- Author:
Yana BAO
1
;
Xiaonan ZHANG
;
Xi GUAN
;
Liang ZHAO
;
Yuying CUI
;
Yu WU
;
Dong SHANG
;
Hong XIANG
Author Information
- Publication Type:Journal Article
- Keywords: Traditional Chinese medicine; Heat-clearing herbs; Anti-inflammatory; Anti-tumor; Medicinal property
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(1):161-167
- CountryChina
- Language:Chinese
- Abstract: Background When discussing the new concept of"pancreas spleen integration"in the early stage,we proposed that dampness heat stagnation in the spleen and deficiency due to stagnation are the traditional Chinese medicine(TCM)pathogenesis elements of pancreatitis-induced pancreatic ductal adenocarcinoma,among which dampness heat is the soil of pancreatitis deteriorates into pancreatic cancer.Objective Based on the TCM pathogenesis elements of pancreatitis to cancer with"damp heat"as the main factor,data mining technology was used to analyze the properties,channel conversion and active ingredients of heat-clearing Chinese medicines with anti-inflammatory and anti-tumor effects,and to summarize the drug characteristics of these Chinese medicines.To prospectively predict the use of drugs in the transformation process of pancreatitis to pancreatic cancer.Methods Taking Traditional Chinese Medicine(10th Edition of China Traditional Chinese Medicine Press)as the drug data source,66 heat-clearing herbs were searched in the literature database of CNKI and PubMed of inflammation * TCM or(inflammation+tumor)* TCM.The active ingredients were analyzed in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).Results Among the 66 heat-clearing drugs(excluding adjunct drugs),58 herbs had anti-inflammatory effects,53 herbs had anti-tumor effects,and 48 herbs had both anti-inflammatory and anti-tumor effects.The three groups of drugs were mainly bitter,sweet and pungent in five flavors,and were mainly liver,stomach,lung,heart and large intestine in meridian affinity.Five flavors and meridian affinity were highly similar.In the TCMSP,the"five principles of drug class"were used to screen the active ingredients of anti-inflammatory and anti-tumor drugs.A total of 1041 active ingredient data were screened,and 798 active ingredient data were screened after duplicate items were deleted.Top three active ingredients were Luteolin,Kaempferol and Acacetin.Conclusion Based on the analysis of five flavors,meridian affinity and active ingredients of heat-clearing medicine,this study found that the anti-inflammatory and anti-tumor effects of these Chinese herbs are highly overlapping,it has important guiding significance for the drug research and clinical prescription of pancreatitis-induced pancreatic ductal adenocarcinoma.
