Pattern Identification and Treatment of Malignant Transformation in Pulmonary Nodules Based on the Theory of"Mass Hardness and Latent Yang"
10.14148/j.issn.1672-0482.2025.1683
- VernacularTitle:基于"痞坚伏阳"理论辨治肺结节恶性演变
- Author:
Huijuan CHENG
1
;
Zhen ZHANG
;
Cuili LIN
;
Weilan LIN
;
Shun CHEN
;
Feng LU
Author Information
1. 福建中医药大学第一临床医学院,福建 福州 350122;福建中医药大学附属第二人民医院,福建 福州
- Publication Type:Journal Article
- Keywords:
pulmonary nodules;
mass hardness;
latent yang;
pathogenic mechanism;
pattern identification and treatment;
cancer toxin
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(12):1683-1690
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary nodules(PNs),a critical imaging indicator for early lung cancer screening,require deeper mechanistic explo-ration of their malignant transformation.Current Western medicine strategies—primarily surveillance—suffer from delayed interven-tion,while traditional Chinese medicine(TCM)theories(e.g.,"phlegm-blood stasis binding")inadequately explain the dynamic pro-gression of malignancy.Integrating You Yi's theory of"where there is mass hardness,there must be latent yang"with modern research on PN malignant transformation,this study proposes a novel pathogenic mechanism of"latent yang as cause,mass hardness as effect":Depressed latent yang drives pro-tumorigenic microenvironments(e.g.,immunosuppression,hypoxic stress,chronic inflammation),leading to the coagulation of phlegm,stasis,fire,and toxins into cancer toxin.Based on this framework,a core therapeutic principle of"dispersing latent yang and intercepting malignant transition in stages"was established,providing a new paradigm for TCM-based early intervention against PN malignancy.
