Dapsone and Tofacitinib in Rheumatoid Neutrophilic Dermatitis:Case Report with Systematic Literature Analysis
10.3870/j.issn.1004-0781.2025.12.024
- VernacularTitle:氨苯砜联合托法替布治疗类风湿性嗜中性皮炎1例并文献复习
- Author:
Xiaohang XIE
1
;
Yuchun CAO
1
;
Yi DUAN
1
Author Information
1. 华中科技大学同济医学院附属同济医院皮肤科,武汉 430030
- Publication Type:Journal Article
- Keywords:
Tofacitinib;
Dapsone;
Rheumatoid neutrophilic dermatitis;
Interleukin-6;
JAK/STAT3
- From:
Herald of Medicine
2025;44(12):2044-2050
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid neutrophilic dermatitis(RND)is a rare skin manifestation specific for rheumatoid arthritis(RA).This article reported an elderly female patient with RND and reviewed the relevant literature.The patient presented with erythema,blisters,and pustules.The diagnosis of RND was confirmed on the basis of her RA history,characteristics of skin le-sions,laboratory examination and histopathologic findings.The combination therapy of dapsone and tofacitinib demonstrated sig-nificant clinical efficacy in this patient.Immunohistochemistry results showed localized interleukin-6(IL-6)aggregation and over-activation of the JAK/STAT3 signaling pathway in the lesions.These results suggest that the IL-6/JAK/STAT3 pathway may be involved in the pathogenesis of RND,and provide theoretical support and clinical justification for targeting the JAK/STAT3 path-way in the treatment of RND.
