Research Progress on the Intervention of Traditional Chinese Medicine in Regulating Inflammatory Response in IgA Nephropathy
- VernacularTitle:中药调控炎症反应干预IgA肾病的研究进展
- Author:
Yongfang LIU
1
;
Li ZHOU
;
Huiyang LIU
;
Rui HUANG
;
Tiantian YIN
;
Zhiying FENG
Author Information
- Publication Type:Journal Article
- Keywords: IgA nephropathy; Inflammation reaction; Signal pathway; Traditional Chinese Medicine
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(12):3108-3117
- CountryChina
- Language:Chinese
- Abstract: IgA nephropathy is the most common primary glomerulonephritis in China,characterized by proteinuria,hematuria,hypertension,edema,etc.The pathological feature is the deposition of immune complexes dominated by IgA in the mesangial area of the glomerulus.The widely accepted framework for its pathogenesis is the"multiple hit hypothesis".The immune complex of IgA1(Gd-IgA1)with galactose deficiency deposits in the mesangial area to activate mesangial cells and produce inflammatory mediators,leading to a critical role in the pathogenesis and progression of IgA nephropathy,and subsequently causing damage to glomerular endothelial inflammatory cell signaling pathways are closely related to the renal injury and progression of IgA cells,podocytes,and renal tubular epithelial cells.Multiple inflammatory cytokines and nephropathy.Corticosteroids an dcytotoxic drugs can intervene in the inflammatory response of IgA nephropathy,but there are many adversereactions,and clinical application is often limited.Compared with single target therapy in modern medicine,traditional Chinese medicine can achieve better therapeutic effects by exerting multi-target effects such as anti-inflammatory,antioxidant,anti fibrotic,and regulating autophagy,making it the first or alternative choice for IgA nephropathy.In recent years,many studies have confirmed that traditional Chinese medicine with anti-inflammatory effects can regulate the transmission of related inflammatory factors and cell signaling pathways in IgA nephropathy,reduce proteinuria,protect renal function,and alleviate pathological damage to renal tissue.This article systematically summarizes the role of inflammatory response in IgA nephropathy and the cell signaling pathways closely related to inflammation,especially the clinical and experimental research progress of traditional Chinese medicine with anti-inflammatory effects in improving IgA nephropathy inflammatory response,in order to provide reference for further research and application of traditional Chinese medicine intervention in IgA nephropathy inflammatory response.
