Research Advances in the Integrated Management of Obesity and Abnormal Remnant Cholesterol Metabolism
10.3870/j.issn.1004-0781.2025.12.005
- VernacularTitle:肥胖与残余胆固醇代谢异常共同管理的研究进展
- Author:
Tian YU
1
;
Zhelong LIU
1
Author Information
1. 华中科技大学同济医学院附属同济医院内分泌科,武汉 430030;国家代谢性疾病中心湖北分中心,武汉 430030;湖北省内分泌与代谢病临床医学研究中心,武汉 430030
- Publication Type:Journal Article
- Keywords:
Remnant cholesterol;
Obesity;
Weight loss;
Lipid metabolism
- From:
Herald of Medicine
2025;44(12):1906-1913
- CountryChina
- Language:Chinese
-
Abstract:
Remnant cholesterol(RC)and obesity share intricate pathophysiological connections,with dysregulated lipoprotein metabolism and insulin resistance serving as key mechanistic links in their development.Current evidence demonstrates that RC levels exhibit significant positive correlations with body mass index and are closely associated with adverse obesity phenotypes-including altered body composition,metabolic complications,and unfavorable clinical outcomes.This review systematically synthesizes pathophysiological mechanisms linking obesity and RC dysmetabolism,integrated management strategies encompassing lifestyle interventions,Conventional lipid-lowering agents,novel target-specific therapies,and anti-obesity pharmacotherapies.Our analysis provides evidence-based clinical guidance to optimize outcomes for patients with obesity-associated RC metabolic disorders.
