The Role of Neuron-Microglia Crosstalk in Depression and the Regulation of Traditional Chinese Medicine
- VernacularTitle:神经元-小胶质细胞串话在抑郁症中的作用及中医药的干预探析
- Author:
Lihua CAO
1
;
Hui ZHAO
;
Hongjuan HE
;
Zhenzhen WANG
;
Xiaoyu WANG
;
Na LI
;
Song GAO
;
Mingsan MIAO
Author Information
- Publication Type:Journal Article
- Keywords: Depression; Neuron-Microglia crosstalk; Traditional Chinese medicine; Synaptic plasticity; Neurogenesis
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2024;26(12):3086-3096
- CountryChina
- Language:Chinese
- Abstract: Depression is a serious mental illness with a complex pathogenesis and a lack of ideal treatment methods.The crosstalk between neurons and microglia is not only crucial for brain development and maturation,but also for the learning and memory abilities of mature brains.The interaction disorder between neurons and microglia is a key factor leading to depression.In addition,neural stem cells and microglia also have complex interactions,and regulating the interaction between the two can promote the production of new neurons.Traditional Chinese medicine has a long history of preventing and treating depression.It can regulate the microglial state transition,protect neurons from damage,promote synaptic plasticity and neurogenesis.In this context,it is promising that clarifying the mechanism of neuronal-microglial crosstalk and the regulation of both by traditional Chinese medicine can yield new strategies for targeted therapeutics of depression.
