Clinical Analysis of Two Cases of Neonatal Thalamic Hemorrhage
10.3870/j.issn.1004-0781.2025.12.018
- VernacularTitle:2例新生儿丘脑出血的临床分析
- Author:
Lei XIAO
1
;
Zhihui RONG
Author Information
1. 华中科技大学同济医学院附属同济医院新生儿科,武汉 430030
- Publication Type:Journal Article
- Keywords:
Neonatal thalamic hemorrhage;
Etiology;
Prognosis
- From:
Herald of Medicine
2025;44(12):1998-2004
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and prognosis of neonatal thalamic hemorrhage.Methods The clinical data of two neonates with thalamic hemorrhage admitted to Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology were retrospectively analyzed.The terms"thalamic hemorrhage""neonate",and"newborn"were searched in the databases CNKI,Wanfang,CQVIP,PubMed,and Web of Science to summarize the reported etiology,clinical features,and prognosis of neonatal thalamic hemorrhage.Results Both cases were diagnosed with unilateral thalamic hemorrhage due to perinatal hypoxia.No seizures or other typical neurological abnormalities were observed.The patients improved after hemostatic and neuroprotective treatment and were discharged.They were followed up regularly until two years of age,with favorable outcomes.A total of 13 relevant studies involving 35 cases were included.Thalamic hemorrhage mostly occurred within the first two weeks of life(31/37 cases,83.78%).Bilateral thalamic hemorrhage accounted for 21.62%(8/37),primarily caused by perinatal asphyxia,while unilateral cases(78.38%,29/37)were mostly associated with cerebral venous sinus thrombosis.Infants with bilateral thalamic hemorrhage or associated ventricular dilatation presented with more severe symptoms,such as generalized tonic seizures,sunsetting sign,thermoregulatory instability,and absent neurological reflexes,and had significantly worse outcomes compared to unilateral cases(P=0.006).In long-term follow-up,42.34%(16/37 cases)exhibited normal neurodevelopment without major neuropsychiatric abnormalities.Among them,those with unilateral thalamic hemorrhage showed relatively better long-term prognosis.In addition,limited case analysis showed no statistically significant association between prognosis and gestational age,sex,time of onset,EEG findings,or status epilepticus.Conclusions The etiology and clinical presentation of neonatal thalamic hemorrhage are heterogeneous.The prognosis significantly differs between bilateral and unilateral hemorrhages.Long-term follow-up is essential to assess the impact on neurodevelopment and neurological function.
