A case of successful ovulation induction and pregnancy with the PPOS regimen after fertility preservation treatment for stage ⅠA grade 2 endometrioid carcinoma combined with balanced chromosomal translocation
10.3760/cma.j.cn101441-20250125-00040
- VernacularTitle:子宫内膜样癌Ⅱ级ⅠA期合并染色体平衡易位患者保留生育功能治疗后PPOS方案促排卵成功助孕1例
- Author:
Pengfei WU
1
;
Xuezhen LUO
;
Hua CHEN
;
Min YU
Author Information
1. 复旦大学附属妇产科医院妇科，上海 200090
- Publication Type:Journal Article
- Keywords:
Grade Ⅱ endometrioid carcinoma;
Fertility preservation treatment;
Balanced chromosomal translocation;
Progestin primed ovarian stimulation;
Preimplantatio
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):725-728
- CountryChina
- Language:Chinese
-
Abstract:
In this case, the patient was 32-year-old. In September 2020, hysteroscopy was performed due to the indication of intrauterine lesion shown by ultrasound. Pathological examination suggested local grade Ⅱ endometrioid carcinoma, and the molecular classification was no specific molecular profile. The patient was treated by gonadotropin-releasing hormone agonist and letrozole and achieved complete response. The chromosome karyotype examination suggests that the female was 46,XX,t(9;14)(q22;q24), and the male was 46,XY. The progestin primed ovarian stimulation regimen for ovulation induction was carried out under the protection of levonorgestrel-releasing intrauterine system. A total of 17 oocytes were retrieved, among which 14 were mature oocytes. Intracytoplasmic sperm injection was used for fertilization, and 13 oocytes were fertilized. On the 3rd day, there were 10 embryos. After blastocyst culture, 6 blastocysts were formed. Six blastocysts were biopsied for preimplantation genetic testing for structural rearrangements, and 1 euploid embryo (B6BB) was obtained. Successful pregnancy was delivered after hormone replacement therapy-frozen embryo transfer, and a healthy male infant was obtained. This case indicates that patients with grade Ⅱ endometrioid carcinoma can achieve complete remission and pregnancy through combined drug treatment. However, a comprehensive assessment should be conducted, and relevant risks should be informed before treatment. For those with balanced chromosomal translocation, preimplantation genetic testing should be actively adopted to block the implantation of aneuploid embryos.
