Progress on key genes in oocyte maturation and its fertilization process
10.3760/cma.j.cn101441-20240928-00357
- VernacularTitle:卵母细胞成熟及其受精过程关键基因的研究进展
- Author:
Jiayao CHEN
1
;
Zhiping ZHANG
;
Shimin WANG
;
Pengfei ZHU
;
Xueqing WU
Author Information
1. 山西医科大学临床学科建设中心，太原 030001
- Publication Type:Journal Article
- Keywords:
Fertilization;
Oocyte maturation;
Gene mutation
- From:
Chinese Journal of Reproduction and Contraception
2025;45(1):90-95
- CountryChina
- Language:Chinese
-
Abstract:
Oocyte maturation disorders and fertilization failures are caused by a variety of factors, including complex factors such as chromosomal abnormalities and poor oocyte quality. With the widespread use of high-throughput sequencing technology, more and more genetic mutations have been found to be associated with oocyte maturation and fertilization process in infertile patients. This paper summarizes and discusses 11 key genes ( TRIP13, TBPL2, LHX8, PATL2, TUBB8, CDC20, WEE2, ZP, ASTL, JUNO and CD9) related to oocyte maturation and fertilization-related disorders in females, providing a basis for research on the prevention of diseases associated with oocyte maturation blockage and fertilization failure and the development of targeted therapies.
