Adolescent health risks in offspring conceived through assisted reproductive technology: mechanisms and research status
10.3760/cma.j.cn101441-20241222-00489
- VernacularTitle:辅助生殖子代青春期健康风险：机制与研究现状
- Author:
Jiayi GAO
1
;
Tian TIAN
1
;
Fang LIU
1
;
Yu FU
1
;
Yuanyuan WANG
1
;
Jie QIAO
1
Author Information
1. 北京大学第三医院妇产科生殖医学中心 国家妇产疾病临床医学研究中心（北京大学第三医院）辅助生殖教育部重点实验室（北京大学）北京市生殖内分泌与辅助生殖技术重点实验室，北京 100191
- Publication Type:Journal Article
- Keywords:
Reproductive techniques, assisted;
Puberty;
Fertility;
Endocrine system;
Offspring health
- From:
Chinese Journal of Reproduction and Contraception
2025;45(4):403-408
- CountryChina
- Language:Chinese
-
Abstract:
The wide application of assisted reproductive technology (ART) has brought the hope of fertility to infertile couples worldwide. However, with the gradual popularization of ART, the long-term health status of ART children has attracted extensive attention from society. Adolescence is a critical developmental period for individuals to transition from childhood to adulthood, with significant physical and psychological changes, so the health status of ART offspring during this period has a profound impact on their overall future health. This article reviews the existing studies, focusing on the effects of ART on multiple aspects of adolescent health, especially growth and development, cardiovascular health, endocrine function, fertility, cancer risk, atopic diseases, mental health, epigenetic changes and other aspects. The possible mechanisms leading to these health problems, including genetic factors, environmental exposures, and the long-term effects of early life interventions, were explored. Future research should continue to explore the long-term effects of ART on the health of offspring and further clarify the mechanisms of these effects, so as to provide a scientific basis for the development of effective prevention and intervention measures.
