Research progress on the immunological pathogenesis of bronchial asthma
10.13431/j.cnki.immunol.j.20250117
- VernacularTitle:支气管哮喘免疫学发病机理的研究进展
- Author:
Ruli ZHAO
1
;
Mengyun LIU
;
Yimei MA
;
Xiao WANG
;
Xiaoying LIU
Author Information
1. 新疆大学生命科学与技术学院,新疆生物资源基因工程重点实验室,乌鲁木齐 830017
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
pathogenesis;
immune response;
review
- From:
Immunological Journal
2025;41(11):842-848
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a common chronic heterogeneous airway disease that is pathologically characterized by airway hyperresponsiveness and chronic inflammation.The pathogenesis of this disease is complex.Essentially,it is an airway inflammatory response driven by abnormal activation of the immune system.Its occurrence and development involve the participation of various immune cells and immune factors,including B lymphocytes,T lymphocytes,mast cells,macrophages and dendritic cells,as well as key cytokines such as interleukin(IL)-4,IL-5,IL-13,and interferon(IFN)-γ.And key cytokines such as interleukin(IL)-4,IL-5,IL-13 and interferon-γ.The complex interactions between these immune cells and mediators cause a series of pathological changes such as increased airway mucus secretion,smooth muscle contraction and airway remodeling,ultimately leading to the appearance of clinical symptoms,such as chest tightness,shortness of breath,wheezing and coughing.This article conducts systematically reviews current understanding of the immunological pathogenesis of bronchial asthma,thereby providing theoretical references for drug development and clinical diagnosis and treatment.
