Clinical application and research progress of granulocyte colony-stimulating factor in the treatment of thin endometrium
10.3760/cma.j.cn101441-20240909-00333
- VernacularTitle:粒细胞集落刺激因子治疗薄型子宫内膜临床应用及作用机制研究进展
- Author:
Xiaoying WANG
1
;
Haixiang SUN
1
;
Guijun YAN
1
Author Information
1. 南京大学医学院附属鼓楼医院生殖医学中心，南京 210008
- Publication Type:Journal Article
- Keywords:
Granulocyte colony-stimulating factor;
Endometrial thickness;
Thin endometrium
- From:
Chinese Journal of Reproduction and Contraception
2025;45(3):295-300
- CountryChina
- Language:Chinese
-
Abstract:
The endometrial thickness is a crucial indicator for pregnancy success. Thin endometrium is typically related to low clinical pregnancy and live birth rate. Current research indicates that granulocyte colony-stimulating factor (G-CSF) is a glycoprotein that recognized as a cytokine and growth factor, which may support the establishment of endometrial receptivity during embryo implantation through promoting angiogenesis, embryo adhesion, and trophoblast invasion, thus increasing the endometrial thickness and clinical pregnancy rate. However, there are still conflicts about the efficacy of G-CSF. Therefore, identifying the pathological mechanism of thin endometrium and how G-CSF promotes endometrial thickness and receptivity has clinical significance. This article will review the progress on clinical research and molecular mechanism of G-CSF in treating thin endometrium.
