Mendelian randomization analysis of circulating white blood cells and juvenile idiopathic arthritis
10.13431/j.cnki.immunol.j.20250113
- VernacularTitle:循环白细胞与幼年特发性关节炎的孟德尔随机化分析
- Author:
Sijie DU
1
;
Guowei ZHANG
1
;
Shumin LI
1
;
Ke GUO
1
;
Chen YAO
1
Author Information
1. 解放军中部战区总医院医疗保障中心,武汉 430070
- Publication Type:Journal Article
- Keywords:
juvenile idiopathic arthritis;
circulating white blood cells;
causal inference;
Mendelian randomization;
neutrophils;
monocytes
- From:
Immunological Journal
2025;41(11):819-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between circulating white blood cells(WBC)and juvenile idiopathic arthritis(JIA)using a two-sample Mendelian randomization(MR)analysis,and to provide a reference for the treatment strategy of JIA.Methods Relevant data of WBC and JIA were extracted from the public data of genome-wide association studies.Then,bidirectional MR analysis was conducted using the inverse variance weighted method(IVW),MR-Egger regression method,mixed contamination method,and Bayesian weighted Mendelian randomization.A series of sensitivity analyses were used to verify the robustness of the results.Results After MR analysis,false discovery rate(FDR)correction and sensitivity verification,calculations using IVW as the main method showed that neutrophils could reduce the risk of JIA(OR=0.752,95%CI:0.622,0.908,P=0.003,PFDR=0.003),and that JIA could lead to increased monocyte counts(bete=0.015,95%CI:0.007,0.022,P=1.90E-04,PFDR=1.14E-03).Conclusion A bidirectional causal association is identified between WBC and the risk of JIA occurrence.
