Expression and clinical significance of serum PG and TREM-1 in patients with reflux esophagitis
10.13431/j.cnki.immunol.j.20250110
- VernacularTitle:反流性食管炎患者血清PG、TREM-1表达及临床意义
- Author:
Wendong ZHAO
1
;
Meng ZHAO
1
;
Jing WANG
1
;
Yuxi HAN
1
;
Li ZHU
1
;
Junchen GE
1
;
Wenjuan GAO
1
;
Xu ZHANG
1
Author Information
1. 联勤保障部队第九六二医院消化内科,哈尔滨 150086
- Publication Type:Journal Article
- Keywords:
reflux esophagitis;
pepsinogen;
triggering receptor expressed on myeloid cells-1;
interleukin;
tumor necrosis factor-α;
receiver operating characteristics
- From:
Immunological Journal
2025;41(11):802-806
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression changes and clinical significance of serum pepsinogen(PG)and triggering receptor expressed on myeloid cells-1(TREM-1)in patients with reflux esophagitis(RE).Methods A total of 140 patients with RE who were treated from October 2021 to October 2023 were selected as the observation group,and 140 healthy adults who underwent physical examination during the same period were selected as the control group.Serum PG(PGⅠ and PGⅡ)and TREM-1 were detected by ELISA.Multivariate logistic regression was used to analyze the influencing factors of RE.Receiver operating characteristic(ROC)was used to analyze the diagnostic efficacy of serum PGⅠ,PGⅡ and TREM-1 levels for RE.Results The levels of interleukin(IL)-2,IL-6,Il-1β,PGⅡ,TREM-1 and tumor necrosis factor-α(TNF-α)in the observation group were significantly higher than those in the control group,while the level of PGⅠ was significantly lower than that in the control group(P<0.01).Serum IL-2,IL-6,IL-1β,TNF-α,PGⅡ and TREM-1 were risk factors for RE,while serum PGⅠ was a protective factor for RE(P<0.01).ROC curve analysis showed that the area under the ROC curve(AUC)of combined detection of PGⅠ,PGⅡ and TREM-1 in the diagnosis of RE was significantly higher than that of PGⅠ alone(Z=5.940,P<0.001)and PGⅡ alone(Z=6.764,P<0.001)and TREM-1 alone(Z=6.791,P<0.001).Conclusion The expression levels of serum PGⅡ and TREM-1 in patients with RE are increased,while the expression level of PGⅠ is decreased.The combined detection of the three can improve the diagnostic efficacy of RE.
