Research status of uric acid metabolism in patients with polycystic ovary syndrome
10.3760/cma.j.cn101441-20240612-00213
- VernacularTitle:尿酸代谢在多囊卵巢综合征患者中的研究现状
- Author:
Tingting LAN
1
;
Jing WANG
1
;
Min DAN
1
;
Yuanyuan LIU
1
;
Mingya CAO
1
;
Zhiming ZHAO
1
Author Information
1. 河北医科大学第二医院生殖科，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Uric acid;
Polycystic ovary syndrome;
Hyperandrogenemia;
Insulin resistance;
Abnormal lipid metabolism;
Ovulation inhibition;
Adipose tissue;
Urate lowering
- From:
Chinese Journal of Reproduction and Contraception
2024;44(10):1015-1020
- CountryChina
- Language:Chinese
-
Abstract:
With the deepening of the research on uric acid, it has been found that abnormal uric acid metabolism is not only related to kidney and cardiovascular diseases, but also closely related to reproductive system diseases such as polycystic ovary syndrome (PCOS). Uric acid can play an important role in the occurrence and development of PCOS through oxidative stress, chronic inflammation and interference with key enzyme activities. PCOS is primarily characterized by hyperandrogenemia, insulin resistance, and dysregulation of glucose and lipid metabolism. Researches have found that there is an interaction between hyperuricemia and hyperandrogenemia, as well as abnormal glucose and lipid metabolism. Additionally, elevated serum uric acid levels are associated with a higher incidence of pregnancy complications and adverse pregnancy outcomes in women with PCOS. However, there are few reviews on this aspect. Therefore, this review aims to provide a more comprehensive scientific basis for the clinical treatment and management of PCOS by deeply exploring the relationship between uric acid metabolism and the main clinical manifestations of PCOS, as well as the impact of abnormal uric acid metabolism on pregnancy outcomes and complications in PCOS patients.
