Advances in the regulation of orexigenic/anorexigenic neuropeptides and signaling pathways by metabolic bariatric surgery
10.7659/j.issn.1005-6947.240634
- VernacularTitle:代谢减重手术调控促食/厌食神经因子及信号通路的研究进展
- Author:
Yangxingyun WANG
1
;
Hengyu DUAN
1
;
Ruibin LI
1
Author Information
1. 内蒙古科技大学包头医学院第一附属医院 日间手术中心,内蒙古 包头 014010
- Publication Type:Journal Article
- Keywords:
Bariatric Surgery;
Feeding Behavior;
Neuropeptides;
Signal Transduction;
Review
- From:
Chinese Journal of General Surgery
2025;34(10):2258-2264
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic bariatric surgery is an effective intervention for obesity and related metabolic disorders.Beyond substantial weight reduction,it modulates orexigenic and anorexigenic neuropeptides and their signaling pathways to improve energy homeostasis and metabolic function.This review summarizes the regulatory effects of various bariatric procedures(such as Roux-en-Y gastric bypass and sleeve gastrectomy)on orexigenic neuropeptides and anorexigenic factors,highlighting the involvement of key signaling pathways including mTOR and AMPK.These mechanisms contribute to weight control,enhanced insulin sensitivity,and remission of metabolic diseases.By integrating central and peripheral regulatory processes,metabolic surgery provides new biological insights into individualized obesity management.Future research should focus on interindividual variability and long-term neuro-metabolic adaptations to optimize surgical outcomes and improve metabolic health.
