Progress of programmed death of granulosa cells in ovarian aging
10.3760/cma.j.cn101441-20240712-00252
- VernacularTitle:颗粒细胞程序性死亡在卵巢衰老中的研究进展
- Author:
Yicen MENG
1
;
Qianjie ZHANG
;
Wenjing MA
;
Zhongming ZHOU
;
Jing YANG
;
Saijiao LI
Author Information
1. 武汉大学人民医院生殖中心 湖北省辅助生育与胚胎发育医学临床研究中心，武汉 430060
- Publication Type:Journal Article
- Keywords:
Ovarian aging;
Granulosa cell;
Programmed cell death;
Diminished ovarian reserve
- From:
Chinese Journal of Reproduction and Contraception
2024;44(11):1210-1214
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian aging is one of the most common reproductive endocrine disorders in women of reproductive age, with an increasing incidence over the years. It is characterized by a decline or depletion of ovarian function, including follicle quantity and/or quality. Depending on the degree of ovarian function decline, it can be classified into diseases including diminished ovarian reserve, premature ovarian insufficiency, premature ovarian failure, etc., which are clinically characterized by ovulatory dysfunction, reproductive endocrine hormone disruption, and ultimately lead to a decline in female fertility. The pathogenesis is complex and varied, and the exact mechanism is unknown to date. Granulosa cells play a key role in ovarian hormone synthesis and disruption development, and many studies have shown that the programmed death of granulosa cells (apoptosis, pyroptosis, autophagy, ferroptosis, cuproptosis, etc.) may be closely related to the occurrence and development of ovarian aging. In this article, we present a systematic review of the relevant literature with the aim of exploring the relationship between programmed cell death in granulosa cells and ovarian aging.
